Boron is a chemical element identified by atoms containing five protons in their nuclei. Naturally, boron exists in two stable isotopes: boron-10 and boron-11. The primary difference between these isotopes is the number of neutrons in their nuclei. Boron-10 has five neutrons, resulting in an atomic mass of 10 AMU, while boron-11 has six neutrons, with an atomic mass of 11 AMU. Among these, B-11 Boron is the most abundant, accounting for about 70-80% of naturally occurring boron on Earth.
B 11 Boron plays a pivotal role in the medical field, particularly in boron magnetic resonance spectroscopy (MRS). This technique is utilized to assess the delivery of boron neutron capture therapy (BNCT) agents to target lesions. BNCT is a cutting-edge cancer treatment that leverages the selective accumulation of boron compounds within cancerous tissues. Boron-11 MRS allows researchers and clinicians to measure the uptake and retention of these compounds in vivo, distinguishing between normal and abnormal tissues in both humans and animals. This capability ensures precise targeting and enhances the effectiveness of BNCT.
While boron-10 and boron-11 are both isotopes of boron, they differ in their neutron count and applications. Boron-10, which makes up about 30% of natural boron, has a unique role in nuclear applications, such as neutron capture processes. On the other hand, boron-11, the more abundant isotope, is extensively used in medical and scientific research. Its higher stability and prevalence make it the preferred choice for advanced therapies like BNCT, showcasing the complementary roles of these two isotopes in various fields.
References
"Boron." Chemical Elements Handbook, National Center for Biotechnology Information, PubChem, https://pubchem.ncbi.nlm.nih.gov/element/Boron.
Matsuura, Tatsuo. "Boron Neutron Capture Therapy (BNCT): Principles and Clinical Applications." Advanced Functional Materials, vol. 19, no. 11, 2009, pp. 1710–1717. DOI:10.1002/adfm.200800880.
Lehnert, Wolfgang. "The Role of Boron in Medical Isotope Therapy." Physics and Applications of Isotopes, Springer, 2014, pp. 143–157.
"Isotopes of Boron." Periodic Table of Isotopes, Royal Society of Chemistry, https://www.rsc.org/periodic-table/isotopes/boron.
Suzuki, Motoo, et al. "Differential Retention of Boron Compounds in Normal and Abnormal Tissues." Cancer Research, vol. 55, no. 17, 1995, pp. 3820–3825.
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